PubMed: Carnosine Supplementation

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PubMed: Carnosine Supplementation

Postby igoeja » August 1st, 2010, 8:01 am

J Appl Physiol. 2010 Jul 29. [Epub ahead of print]
Important role of muscle carnosine in rowing performance.
Baguet A, Bourgois J, Vanhee L, Achten E, Derave W.

University Ghent.


The role of the presence of carnosine (beta-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral beta-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes.

The aims of the present study were to investigate if performance is related to the muscle carnosine content and if beta-alanine supplementation improves performance in highly-trained rowers. Eighteen Belgian elite rowers were supplemented for 7 weeks with either placebo or beta-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2000 m ergometer test.

At baseline, there was a strong positive correlation between 100 m, 500 m, 2000 m and 6000 m speed and muscle carnosine content. After beta-alanine supplementation, the carnosine content increased by 45.3 % in soleus and 28.2 % in gastrocnemius. Following supplementation, the beta-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (p=0.07). Muscle carnosine elevation was positively correlated to 2000 m performance enhancement (p=0.042 and r=0.498).

It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance. ... t=Abstract
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